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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Int J Cancer. 2012 Apr 24;131(9):2143–2152. doi: 10.1002/ijc.27471

Figure 3.

Figure 3

Effect of cixutumumab on viability of established (A) and early passage (B) mesothelioma cells. The results are shown as % growth inhibition at 100 μg/mL of cixutumumab for each cell line. Pearson correlation analysis was performed using Graph pad to show the correlation between the activity of cixutumumab and surface IGF-IR sites/cell expressed by established (Aa) and early passage (Bb) mesothelioma cells. (C) H28 cells were treated with control si-RNA or IGF-IR siRNA for 48hr. Western blot analysis (Cc) was done to determine the expression level of IGF-IR after knockdown. Two days after transfection with either control si-RNA or IGF-IR si-RNA, H28 cells were treated with cixutumumab for 72 hr and cells viability was evaluated by ATP Lite assay. SD is shown for each treatment group. p<0.02