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Effect of cixutumumab on IGF-IR downstream signaling pathway in H226, H28 and H2052 cell lines. Phosphorylation-dependent activation of downstream signaling molecules (p-IGF-IR, p-Akt and p-Erk) was analyzed by western blot with phosphorylation site–specific antibodies. Total protein expression of each molecule (t-IGF-IR, t-Akt and t-Erk) was analyzed.
