Figure 6.
Anti-tumor efficacy of cixutumumab in a mesothelioma xenograft model. Athymic nude mice were injected i.p. with 5×106 H226 mesothelioma cells and were randomized to receive either saline or cixutumumab 50 mg/kg i.p. (A) Graph shows significant decrease in the total flux counts in the cixutumumab treated group as compared to the saline treated group. Each data point is the median of 9 mice per treatment group. SD is shown for each point. * P<0.05 (B) Whole-body non-invasive imaging of visible light emitted by luciferase expressing mesothelioma cells is shown for each mouse at days 24 and 60. (C) Kaplan-Meier curve showing the overall survival in cixutumumab treated group in comparison to saline treated control group.