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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Biochim Biophys Acta. 2012 Mar 6;1819(7):716–726. doi: 10.1016/j.bbagrm.2012.02.019

Figure 2. Key Transition Points During GR signaling.

Figure 2

After ligand binding dimerizes the Glucocorticoid Receptor (GR), it enters the nucleus and binds target sequences such as the Glucocorticoid Response Element (GRE) within chromatin. The receptor binds co-regulators such as NcoA1/SRC-1, NCoA2/TIF-2/GRP-1, and CBP/p300 which do not require remodeling to engage the receptor at the promoter. Next, the BRG1 complex SWI/SNF is recruited to the promoter through an interaction with GR and nucleosomes are repositioned. This allows transcription factors such as NF1 and the octamer transcription factors (OTFs) as well as the TATA-binding protein (TBP). Finally, mediator proteins are recruited and the preinitiation complex forms leading to transcripton by RNA Pol II.