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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Pharmacoepidemiol Drug Saf. 2012 Jan 4;21(6):631–639. doi: 10.1002/pds.2347

Appendix Table 2. Performance characteristics of 4 hypothetical methods across 10 hypothetical examples*.

Hypothetical
methods		 Scenario-based approach Event-based approach
TP FP FN TN Overall
sensitivity		 Overall
specificity		 a b c d Event-
based
sensitivity		 Event-
based
specificity		 EBP* EBP**
1 2 2 2 2 0.500 0.500 20 20 100 100 0.167 0.833 0.700 0.767
2 2 2 2 2 0.500 0.500 20 10 100 110 0.167 0.917 0.767 0.842
3 3 2 1 2 0.750 0.500 65 20 55 100 0.542 0.833 0.775 0.804
4 3 1 1 3 0.750 0.750 65 5 55 115 0.542 0.958 0.875 0.917

FN, false negatives; FP, false positives; TN, false negatives; TP, true positives

*

With wi = 0.20

**

With wi = 0.10