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. Author manuscript; available in PMC: 2013 Jun 1.

Published in final edited form as: J Inorg Biochem. 2012 Feb 24;111:187–194. doi: 10.1016/j.jinorgbio.2012.02.011

A superposition of the catalytic and inhibitory complexes (based on C_α positions) shows how well the inhibitor molecules match those of the substrate/product; (left) TSP (in silver, lighter color) and PGA (in orange, darker color); (right) LAP (in silver, lighter color) and PEP (in orange, darker color). Electron density is from the heteroinhibitory complex.

A superposition of the catalytic and inhibitory complexes (based on C_α positions) shows how well the inhibitor molecules match those of the substrate/product; (left) TSP (in silver, lighter color) and PGA (in orange, darker color); (right) LAP (in silver, lighter color) and PEP (in orange, darker color). Electron density is from the heteroinhibitory complex.