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. Author manuscript; available in PMC: 2013 Jul 7.
Published in final edited form as: Analyst. 2012 Feb 8;137(13):2997–3003. doi: 10.1039/c2an16173g

Figure 1.

Figure 1

Figure 1

Structures of 2SBPO-Casp(A) and 2SBPO(B). The aspartic acid group renders the probe cell permeable and non-fluorescent. Upon cleavage (C), 2SBPO is retained in cells, generating a strong fluorescence signal (a synthetic scheme for (A) and (B) are found in Electronic Supplementary Information).