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Gentamicin induces ROS generation (measured as DCF fluorescence intensity in the ROS assay) significantly greater than background (second bar). Pretreatment for one hour with UcnII, which specifically activates CRFR2, protects cells against gentamicin-induced ROS formation (third bar), and normalizes the ROS levels to control values. Reprinted from Basappa et al., 2010 with permission)
