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Recovery from FV induced leukemia is influenced by MHC genes (H-2) and Rfv-3
| Mouse strain | H-2 | Rfv-3† | Day 30
postinfection*
|
Recovery from FV leukemia | |
|---|---|---|---|---|---|
| FV viremia | FV neutralizing antibody | ||||
| A.BY | b/b | s/s | + | − | no |
| (C57BL/10 × A.BY)F1 | b/b | s/r | − | + | yes |
| A/WySn | a/a | s/s | + | − | no |
| (B10.A × A/WySn)F1 | a/a | s/r | − | + | no |
All of these mouse strains have similar levels of viremia at 10-14 days postinfection with FV.
s/r mice are similar to r/r mice in recovery from viremia and antibody production.
