Table 3.

Risk for bias in the published controlled trials

Authors (year)	Allocation system described	Allocation concealment	Blinding: patient	Blinding: personnel	Blinding: assessor	Handling of missing data	Power calculation for number of patients to be treated
Kindler et al. (2010)14	Yes	NA	Yes	Yes	NA	Unclear	Yes
Philip et al. (2010)12	Yes	NA	NA	NA	NA	Unclear	Yes
Moore et al. (2007)10	Yes	NA	Yes	Yes	NA	Unclear	Yes
Bramhall et al. (2002)11	Yes	NA	Yes	Yes	NA	Unclear	Yes
van Cutsem et al. (2004)13	Yes	NA	Yes	Yes	NA	Unclear	Yes
Kindler et al. (2011)23	Yes	Yes	Yes	Yes	NA	Unclear	Yes
Oettle et al. (2005)24	Yes	NA	Yes	NA	NA	Unclear	Yes

NA, not available.