Fig. 6.

Effect of βarr2 deletion on signaling protein expression in CF mouse nasal epithelium. (A) The expression of NOS2 and RhoA were examined in sibling WT mice (n = 6), Cftr ^−/− (CF) mice (n = 4), and Cftr ^−/−; barr2 ^−/− DKO mice (n = 5). Significance determined by ANOVA. Comparisons between groups was performed with the Newman-Keuls posthoc test; *P < 0.05. (B) The effect of Rp-cAMPS on NOS2 expression in Cftr ^−/− mouse nasal epithelium. Cftr ^−/− mice were treated with either saline or Rp-cAMPS for 12 days and assayed for NOS2 expression normalized to actin content. Significance determined by t-test; n = 10 for each group.