. Author manuscript; available in PMC: 2013 Oct 1.

Published in final edited form as: Pediatr Blood Cancer. 2012 Mar 2;59(4):605–610. doi: 10.1002/pbc.24105

Table V.

Significant Gene-Environment Interactions Associated with Childhood M/PNET

Pollutant	Gene	RefSNP	OR^a	95% CI	P-value	Q-value^b
Methylene chloride	OGG1	rs293795	4.48	1.35, 14.87	0.01	0.17
	NAT2	rs4271002	4.88	1.36, 17.58	0.02	0.17
	GSTM3	rs7483	2.93	1.06, 8.06	0.03	0.28
Perchloroethylene	NAT2	rs4271002	4.40	1.22, 15.91	0.02	0.23
Trichloroethylene	OGG1	rs293795	9.24	2.24, 38.24	0.002	0.04
	OGG1	rs159150	6.50	1.70, 24.81	0.006	0.07
	ERCC1	rs1007616	0.19	0.05, 0.78	0.02	0.16
Vinyl chloride	NAT1	rs13253389	0.05	0.01, 0.39	0.004	0.09
	CYP1B1	rs1800440	4.15	1.17, 14.67	0.03	0.27
	EPHX1	rs1051740	0.17	0.03, 0.95	0.04	0.27
	ERCC1	rs1007616	0.29	0.08, 0.99	0.04	0.27

Abbreviations: CI, confidence interval; OR, odds ratio;

Adjusted for population stratification using ancestry informative markers;

P-value corrected for multiple comparisons using false discovery rate