TABLE 3.

Summary of calculated incidence rates for specific adverse events related to colonoscopy stratified by patients 65 years of age and older and 80 years of age and older

	No. of adverse events/no. of colonoscopies	Incidence per 1000 colonoscopies (95% CI)
Patients ≥65 y
Cumulative GI adverse events	1419/54,592	26.0 (25.0–27.0)
Perforation	254/248,732	1.0 (0.9–1.5)
GI bleeding	345/54,592	6.3 (5.7–7.0)
Postpolypectomy bleeding*	5/1372	3.6 (1.2–8.5)
CV/pulm	1044/54,592	19.1 (18.0–20.3)
Severe†	661/54,592	12.1 (11.2–13.1)
Nonsevere†	753/54,592	13.8 (12.8–14.8)
Mortality	53/54,592	1.0 (0.7–2.2)
Patients ≥80 y
Cumulative GI adverse events	491/14,082	34.9 (31.9–38.0)
Perforation	71/47,076	1.5 (1.1–1.9)
GI bleeding	9/3699	2.4 (1.1–4.6)
Postpolypectomy bleeding	9/3699	2.4 (1.1–4.6)
CV/pulm	413/14,285	28.9 (26.2–31.8)
Severe‡	2/3902	0.5 (0.06–1.9)
Nonsevere‡	126/3902	32.3 (27.0–38.3)
Mortality	2/3814	0.5 (0.06–1.9)

CI, Confidence interval; CV/pulm, cardiovascular/pulmonary.

^*Data only available from 3 studies.^20,23,26

^†Severe and nonsevere CV/pulmonary adverse events do not add up to the total CV/pulmonary adverse events because patients may have had more than 1 adverse event in each subgroup.

^‡Severe and nonsevere CV/pulmonary adverse events do not add up to the total CV/pulmonary adverse events because data from the Warren et al¹⁶ study could not be abstracted into severe and nonsevere for patients 80 years of age and older.