. Author manuscript; available in PMC: 2013 Jun 15.

Published in final edited form as: Biol Psychiatry. 2012 Apr 27;71(12):1090–1098. doi: 10.1016/j.biopsych.2012.03.013

Table 1. Hippocampal changes in FGFR2cKO mice lacking FGFR2 embryonically and in adulthood.

Averages and standard error of the mean (n for each shown) for volumes and cell numbers assessed by stereology. n=number of animals. Differences were assessed with one tailed student’s t-tests based on previous reductions of these volumes and cell types in FGFR2cKO and FGFR1cKO animals (7). BrdU was injected 1 hour prior to analysis.

	Controls	FGFR2cKO	Deficit
Dentate Gyrus	4.49 ± 0.21	2.97 ± 0.29	−33.9%
Volume (mm³)	n=6	n=6	p<0.001
Total	22.45 ± 1.18	14.16 ± 1.06	−36.9%
Hippocampal	n=6	n=6	p<0.001
Volume (mm³)
Total	43.70 ± 2.92	24.30 ± 1.20	−44.4%
Hippocampal	n=5	n=5	p<0.0005
Parvalbumin Cell
Number (×10³)
Dentate Gyrus	3.55 ± 0.14	2.85 ± 0.15	−19.6%
Doublecortin Cell	n=6	n=6	p<0.01
Number (×10³)
Dentate Gyrus	3.43 ± 0.71	1.97 ± 0.35	−42.5 %
BrdU+ Cell	n=6	n=6	p<0.05
Number (×10³)