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. 2012 May 31;2012:207235. doi: 10.5402/2012/207235

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Copyright © 2012 Jianyuan Chai et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

CCN1 upregulates gene expression of ITGA11 and ITGB5 in esophageal epithelial cells. Cells were cultured in the absence (control) or presence of CCN1 for the times indicated. Total RNA was isolated and reverse-transcribed with Biotin-16-dUTP to generate cDNA probes, which were then hybridized to the cDNA microarrays. (a) Array layout with integrins is marked in bold. Integrins further analyzed in the study are in red. (b) Gene expression profile with marked (circled) integrins of interest. ITGA11 and ITGB5 are upregulated by CCN1.