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. 2012 May 2;32(18):6072–6080. doi: 10.1523/JNEUROSCI.6486-11.2012

Figure 5.

Figure 5.

Activation of NET but not DAT is required for the AMPH-induced increase in glutamate transmission. A, Plot shows application of the NET inhibitor nisoxetine prevents increase in glutamate transmission with AMPH (AMPH, 139 ± 6%; n = 6; AMPH + Nisoxetine, 103 ± 5%; n = 8; p < 0.003). B, Plot shows application of SKF increases glutamate transmission in the presence of nisoxetine even though prior application of AMPH failed to increase transmission (AMPH + Nisox, 104 ± 2%; SKF, 122 ± 6%; n = 6; p < 0.04). C, Plot shows application of the DAT inhibitor GBR12935 does not prevent the AMPH-mediated increase in glutamate transmission (GBR12935, 128 ± 6%; n = 6; AMPH vs AMPH + GBR p > 0.05). Error bars indicate SEM.