. Author manuscript; available in PMC: 2012 Jun 10.

Published in final edited form as: J Nat Prod. 2011 Mar 31;74(4):852–856. doi: 10.1021/np100763p

Table 2. Zone Unit Differentials in the Disk Diffusion Soft Agar Colony Formation Assay^a and IC₅₀ values for Compounds 1 – 7.

	murine tumor selectivity		toxicity to human colon cancer cell line HCT-116
compound	conc. (μg/disk)	Z_C38– Z_L1210	IC₅₀ (μg/disc)
1	68	300	7.5
2	66	300	18
3	NA^b		>46
4	1.9	600	30
5	0.23	500	0.045
6	0.26	450	0.055
7	0.24	550	0.040

Measured in zone units: 200 zone units = 6 mm. Murine cell lines: C38 (colon adenocarcinoma), L1210 (lymphocytic leukemia).

NA = Not active.

Table 2. Zone Unit Differentials in the Disk Diffusion Soft Agar Colony Formation Assaya and IC50 values for Compounds 1 – 7.