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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Gastroenterology. 2011 Nov 19;142(3):543–551.e7. doi: 10.1053/j.gastro.2011.11.020

Figure 2. 4-HNE damages DNA.

Figure 2

A and B, HCT116 (A) and YAMC (B) cells were synchronized to G1 and treated with 4-HNE. FACS analysis shows G2M arrest 48 hrs post-treatment for both cell lines. C–F, Exposure of HCT116 (C) and YAMC (E) cells to 4-HNE generates γH2AX foci in dose-dependent manner. FACS analyses show γH2AX positivity in HCT116 (D) and YAMC (F) cells following 4-HNE treatment. Filled trace, untreated control; open trace, 4-HNE treatment.