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. Author manuscript; available in PMC: 2013 Apr 21.
Published in final edited form as: Chem Soc Rev. 2012 Jan 26;41(8):3025–3038. doi: 10.1039/c2cs15297e

Fig. 2.

Fig. 2

Energy profile for a reaction proceeding from reactants (R) to products (P) via a transition state (TS). The energy barrier for the reaction (ΔE‡) is the difference in energy between the reactants and transition state. The example reaction given here is the Claisen rearrangement of chorismate to form prephenate, which is catalysed by the enzyme chorismate mutase (see Section 5.2).