Skip to main content
. 2011 Sep 21;31(38):13420–13430. doi: 10.1523/JNEUROSCI.2075-11.2011

Figure 2.

Figure 2.

Genetic deletion of MAGL altered eCB/CB1 receptor-mediated responses in CA1 pyramidal neurons. A, Sample traces of IPSCs (top) and averaged DSI (bottom) in CA1 pyramidal neurons in MAGL+/+ and MAGL−/− mice (n = 9–10 cells; N = 3–5 mice). The solid lines are single exponential fitting curves of the decay of DSI. B, Summary of the decay time constant (τ) (left) and magnitude (right) of DSI in MAGL+/+ and MAGL−/− mice (n = 9–10; N = 3–5; *p < 0.05). C, Bath application of the CB1 receptor antagonist AM251 (2 μm) increased the amplitude of evoked IPSCs in hippocampal CA1 pyramidal neurons in MAGL−/− mice but did not significantly affect IPSCs in MAGL+/+ mice (n = 7–8; N = 3–4 mice; p < 0.05). D, Bath application of the CB1 receptor agonist WIN55212-2 (2 μm) induced significantly less depression of IPSCs in MAGL−/− mice than that in MAGL+/+ mice (n = 7–8; N = 3–4; p < 0.05). Error bars indicate SEM.