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. 2011 Sep 21;31(38):13420–13430. doi: 10.1523/JNEUROSCI.2075-11.2011

Figure 4.

Figure 4.

The mechanisms for facilitation of TBS-LTP induction in MAGL−/− mice. A, In the presence of the CB1 receptor antagonist SR141716 (2 μm), TBS-induced LTP in the CA1 region of hippocampal slices was not significantly different between MAGL+/+ and MAGL−/− mice (n = 7–8; N = 4–5 mice; p > 0.05). B, Bath application of SR141716 (2 μm) did not significantly affect basal fEPSPs in MAGL+/+ and MAGL−/− mice (n = 6–7; N = 3–4; p > 0.05). C, TBS-LTP induced in the presence of GABAA receptor blocker picrotoxin (50 μm) was not significantly different between MAGL+/+ and MAGL−/− mice (n = 7–8; N = 5 each; p > 0.05). D, Summary of 15 burst TBS-induced LTP under various experimental conditions (*p < 0.05; **p < 0.01). SR, SR141716; PTX, picrotoxin. Error bars indicate SEM.