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. 2011 Sep 21;31(38):13420–13430. doi: 10.1523/JNEUROSCI.2075-11.2011

Figure 7.

Figure 7.

MAGL−/− mice exhibited enhanced spatial learning in the Morris water maze test. A, MAGL+/+ and MAGL−/− mice were pretreated with vehicle or AM251 and trained for 6 d to find the hidden platform. The escape latency was significantly decreased at the third and fourth days in vehicle-treated MAGL−/− mice (N = 9) compared with that in vehicle-treated MAGL+/+ mice (N = 9; *p < 0.05). There was no significant difference in the escape latency between AM251-treated MAGL+/+ (N = 8) and MAGL−/− mice (N = 8; p > 0.05). B, Vehicle- or AM251-treated MAGL+/+ and MAGL−/− mice exhibited similar swimming speed in the pool during the 6 d training sessions (p > 0.05). C, During probe test, the platform was removed from the pool; all groups of MAGL+/+ and MAGL−/− mice exhibited preference for the targeted quadrant over the other three quadrants (p < 0.001); however, vehicle-treated MAGL−/− mice spent more time searching in the targeted quadrant than vehicle-treated MAGL+/+ mice (**p < 0.01). AM251 treatment significantly decreased the time spent in the targeted quadrant in MAGL−/− mice (p < 0.01). D, During the probe test, the latency to targeted platform location was not significantly different among vehicle- or AM251-treated MAGL+/+ and MAGL−/− mice (p > 0.05). E, Representative swimming tracings of vehicle-treated MAGL+/+ and MAGL−/− mice during the probe test. Error bars indicate SEM.