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. Author manuscript; available in PMC: 2015 Jan 28.
Published in final edited form as: Cancer Lett. 2012 Mar 1;342(2):10.1016/j.canlet.2012.02.018. doi: 10.1016/j.canlet.2012.02.018

Figure 1. A postulated hypothetical epigenetic progression model.

Figure 1

DNA hypermethylation of CDKN2B, CDKN2A, APC, BRCA2, DAPK1, HIC1, TP73, and ESR1 suggest early events in the tumorigenesis continuum from benign to primary SCC. CDH13, CHFR, IGSF4, and RARB (bolded) appear to be primary tumor-specific events and KLK10 and FHIT progression to metastasis-specific events.