Table 2.
Methylation events in sinonasal papillomas
| Biopsies | TIMP3 | APC | CDKN2A | MLH1 | CDKN2B | TP73 | FANCD2 | DAPK1 | ESR1 | GSTP1 | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Case 1 - IP | 1 - Reference | M | M | M | M | M | M | ||||
| (recurrent) | 2 - 10 months | M | M | M | |||||||
| 2 - 10 months | M | ||||||||||
| Case 2 - IP | 1 - Reference | M | |||||||||
| (recurrent) | 2 - 6 months | M | M | M | M | ||||||
| Case 3 - IP | 1- Reference | M | |||||||||
| Case 4 - IP/EP | 1- Reference | M | M | ||||||||
| Case 5 - IP/EP | 1- Reference | M | |||||||||
| Case 6 - EP | 1- Reference | M | M | ||||||||
| Case 7 - EP | 1- Reference | M | |||||||||
| Number of methylated genes/7 cases | 1/7 | 1/7 | 2/7 | 1/7 | 6/7 | 2/7 | 1/7 | 1/7 | 2/7 | 1/7 |
M = methylated
IP = inverted papilloma
EP = exophytic papilloma
IP/EP = inverted and exophytic papilloma