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. Author manuscript; available in PMC: 2012 Jun 11.
Published in final edited form as: J Biol Inorg Chem. 2010 Mar 11;15(5):737–748. doi: 10.1007/s00775-010-0642-1

Fig. 6.

Fig. 6

Drug–protein binding patterns of KP1019 in pulsing experiments. KB-3-1 cells were treated with 50 μM KP1019, and after 3-h drug exposure drug-containing medium was replaced with fresh, drug-free cell culture medium. SEC-ICP-MS of cytosolic fractions was performed 24 h after the beginning of the experiment. Cytosolic fractions of cells treated for 3 and 24 h were prepared and analyzed in parallel. The respective cell numbers for the experiment were 1.58 × 107, 3.2 × 107, and 2.95 × 107 for the 3-, 3–24-, and 24-h samples