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. Author manuscript; available in PMC: 2013 Mar 20.
Published in final edited form as: Cancer Cell. 2012 Mar 20;21(3):418–429. doi: 10.1016/j.ccr.2012.01.007

Figure 1. Evolution of the desmoplastic reaction in murine (mPDA) and human PDA (hPDA).

Figure 1

(A-E) Masson’s trichrome histochemistry shows robust collagen deposition (blue) at all stages of disease.

(F-J) Movat’s pentachrome histochemistry reveals collagen (yellow), GAGs and mucins (blue), and their co-localization (turquoise/green).

(K-O) Histochemistry with HA-binding protein (HABP) reveals intense HA content beginning with preinvasive disease (PanIN).

(P-T) Activated PSC express α-smooth muscle actin (α-SMA) and are abundant in preinvasive (Q), invasive (R) and metastatic mPDA (S) and hPDA (T), but not in normal pancreata (P). ac, acini; is, islet; d, duct; v, venule; h, hepatic parenchyma; *, metastatic lesions. Scale bars, 25 μm.

See also Figure S1.