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. 2012 May 15;8(5):707–718. doi: 10.7150/ijbs.4231

Figure 2.

Figure 2

Effects of Ischemic conditioning in solo or combined protocols and GSP on the activities of ALT and AST in serum. (A) Experimental protocols of individual or combined pre- and post- conditioning protocols. Direct mechanical preconditioning (IpreC-H): The portal triad was occluded for 5 minutes followed by reperfusion for 5 minutes, repeated three times before hepatic ischemic, reperfusion procedures. Remote ischemia preconditioning of hind limb (IpreC-L): The hind limbs of the mice were tightly binding by hemostasis clips for 10 minutes followed by reperfusion for 10 minutes, repeated three times before hepatic ischemic, reperfusion procedures. Dotted areas represent the periods of ischemia; Black areas represent the periods of perfusion. GSP preconditioning: The mice received GSP preconditioning were injected GSP intraperitoneally 20mg/kg/per day for three weeks before using. (B) ALT and AST activities in mice serum were measured at 1 hour after perfusion. (mean ±s, n=7). (* indicate P<0.05 when compared with control group; #indicate P<0.05 when compared with IpostC-2 group). GSP could further reduce the activities of ALT and AST in combined remote preconditioning and postconditioning groups. (mean ±s, n=7). (* indicate P<0.05 when compared with control group; #indicate P<0.05 when compared with IpostC-2 group; ▲indicate P<0.05 when compared with IpreC-H/ IpostC-2 and IpreC-L/ IpostC-2).