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. 2012 May 9;32(19):6688–6698. doi: 10.1523/JNEUROSCI.0081-12.2012

Figure 4.

Figure 4.

Different SPA interneurons display similar intrinsic electrophysiological properties; firing diversity only emerges in GDP interneurons. A, Electrophysiological recordings in current-clamp mode at resting membrane potential (I = 0 pA) in the presence of blockers of synaptic transmission (10 μm bicuculline, 10 μm NBQX, 40 μm APV) from the three SPA interneurons (SPA#1–3) and the three GDP interneurons (GDP#1–3) illustrated in Figure 3A from P4 GAD67-KI-GFP mice. Scale bars: x-axis, 1 s; y-axis, 20 mV. B, Firing patterns in response to a depolarizing current step (+40 pA). Scale bars: x-axis, 5 s; y-axis, 10 mV. Note that at the same developmental stage (P4),a basket-like SPA interneuron (SPA#3; Fig. 3A) presents a strongly delayed and adapting firing pattern while a basket-like GDP interneuron (GDP#3; Fig. 3A) displays a fast-spiking pattern. C, Diagram representing the distribution of different firing patterns recorded in SPA interneurons (n = 11). NA, Non-adaptating; IS, irregular-spiking; Stut, stuttering. Note that SPA interneurons display similar intrinsic electrophysiological properties with an adapting firing pattern and recurrent membrane potential oscillations at resting membrane potential; GDP interneurons display a diversity of firing patterns.