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. Author manuscript; available in PMC: 2012 Jun 11.
Published in final edited form as: Biochem Pharmacol. 2007 Mar 12;73(12):1873–1886. doi: 10.1016/j.bcp.2007.03.002

Fig. 4.

Fig. 4

Impact of MDR modulators on KP772 anticancer activity. KB-3-1 cells and the ABCB1-overexpressing subline KBC-1 were incubated for 72 h with increasing concentrations of KP772 in combination with the ABCB1/ABCC modulators (A) VP (10 μM) and CSA (1 μM) and (B) R(+)VP (10 μM) and dipyridamole (10 μM) as indicated. Values given are means ± S.D. of one representative experiment performed in triplicate. At least three experiments were done delivering comparable results. (C) Impact of dipyridamole (10 μM) and PRO (1 mM) on KP772-treated GLC-4/adr cells. (D) Lanthanum levels of KB-3-1 (full bars) and KBC-1 cells (open bars) were measured by ICP-MS after 1 h incubation with the indicated KP772 concentrations. Means ± S.D. of at least three experiments are given.