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. Author manuscript; available in PMC: 2012 Jun 11.
Published in final edited form as: J Biol Inorg Chem. 2011 Dec 22;17(3):409–423. doi: 10.1007/s00775-011-0864-x

Fig. 10.

Fig. 10

Effect of extracellular superoxide dismutase (SOD) and catalase (CAT) on thiol-induced ROS generation. a Influence of SOD and CAT cotreatment (100 U/mL) on the NAC-induced (2 mM) ROS formation by Cu-Triapine (25 μM) in HL60 cells was determined using DCF-DA. Fluorescence was measured by flow cytometry. One representative experiment of three giving comparable results is shown. Significant differences were calculated by Student’s t test: two asterisks p < 0.01, three asterisks p < 0.001. b Left impact of CAT cotreatment (100 U/mL) on the anticancer activity of Cu-Triapine in the presence and absence of NAC. Right protective effects of CAT against H2O2-induced cell death. Cell viability was determined by MTT assay after 72 h drug treatment