Table 4.
Comparison of the distribution of Conservation Index and LGO score.
| Dataset | Conservation Index (CI) |
LGO score |
||||||
|---|---|---|---|---|---|---|---|---|
| M[D] | M[N] | d | p-value | M[D] | M[N] | d | p-value | |
| CNO | 61.0 | 47.8 | 0.21 | 2.5×10−61 | 56.2 | 9.0 | 0.87 | 0 |
| Consensus | 71.0 | 42.1 | 0.44 | 0 | 62.9 | 8.8 | 0.92 | 0 |
| Not Consensus | 48.8 | 63.1 | −0.22 | 9.4×10−26 | 47.6 | 10.1 | 0.78 | 0 |
M[D] and M[N] are the median values for cancer-causing (D) and neutral (N) variants respectively. d is the distance between the cumulative distributions of cancer-causing and neutral variants. P-value is associated to Kolmogorov–Smirnov test.