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Modulation of Kv4 channels. Left panel. Studies in heterologous cells have revealed diverse roles for auxiliary subunit-dependent phosphorylation of Kv4.2, including forward trafficking from ER though Golgi to the plasma membrane. T38 and S552 refer to Kv4.2 phosphorylation sites. Right panel. Activity-dependent changes in Kv4.2 phosphorylation, mediated by enzymes associated with AKAP79/150, lead to changes internalization of Kv4.2 channels via endocytosis.
