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. Author manuscript; available in PMC: 2013 May 24.
Published in final edited form as: J Med Chem. 2012 May 16;55(10):4847–4860. doi: 10.1021/jm300396n

Figure 2.

Figure 2

Functional agonism by the tested in an assay of adenylate cyclase in membranes of CHO cells expressing the hA3AR. Activity of the 2-(3,4-difluorophenylethynyl)-N6-3-chlorobenzyl-5′-N-methyluronamide-(N)-methanocarba analogue 31 (EC50 value 1.2±0.7 nM). The full agonist 5′-N-ethyluronamidoadenosine 48 was included for comparison (representing 100% efficacy). The experiment was repeated three times, and the average is shown.

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