Table 1.
Clinical profile and ApoE polymorphism in the study population.
| Alzheimer's dementia (AD) (n = 209) | Non-Alzheimer's dementia (nAD) (n = 122) | Individuals with parental history of AD (f/hAD) (n = 70) | Control individuals with no parental history of dementia (NC) (n = 193) | P value (comparing AD and NC) | P value (comparing nAD and NC) | |
|---|---|---|---|---|---|---|
| Mean age in years | 61.14 ± 11.40 | 61.73 ± 12.41 | 37.27 ± 8.87 | 60.35 ± 15.65 | 0.56++ | 0.41++ |
| M : F | 105 : 104 | 75 : 47 | 51 : 19 | 114 : 79 | 0.076* | 0.67* |
| DM, n (%) | 37 (17.7) | 17 (13.9) | 3 (4.3) | 12 (6.2) | 0.0004* | 0.02* |
| HMSE | 12.71 ± 7.60 | 14.19 ± 8.19 | 30 ± 1 | 30 ± 1 | <0.0001 ++ | <0.0001 ++ |
| EASI | 8.41 ± 2.76 | 8.19 ± 3.03 | 0 | 0 | <0.0001 ++ | <0.0001 ++ |
| E2E2, n (%) | 0 (0) | 1 (0.8) | 0 (0) | 0 (0) | 1+ | 0.39+ |
| E2E3, n (%) | 11 (5.3) | 11 (9) | 5 (7.1) | 23 (11.9) | 0.017* | 0.42* |
| E3E3, n (%) | 100 (47.8) | 82 (67.2) | 48 (68.6) | 138 (71.5) | <0.0001* | 0.42* |
| E2E4, n (%) | 13 (6.2) | 4 (3.3) | 0 (0) | 2 (1) | 0.007 + | 0.21+ |
| E3E4, n (%) | 71 (34) | 22 (18) | 16 (22.9) | 30 (15.5) | <0.0001* | 0.56* |
| E4E4, n (%) | 14 (6.7) | 2 (1.6) | 1 (1.4) | 0 (0) | 0.0001 + | 0.15+ |
| Total ApoE4 carrier, n (%) | 98 (46.9) | 28 (23) | 17 (24.3) | 32 (16.6) | <0.0001* | 0.16* |
| ApoE4 carrier with DM, n (%) | 20 (9.6) | 4 (3.3) | 0 (0) | 2 (1) | 0.0001 + | 0.21+ |
HMSE: Hindi Mental Status Examination (indicates level of cognitive function; highest score possible = 31).
EASI: Everyday Abilities Scale for India (indicates level of functional disability, highest score possible = 12).
P values calculated by unpaired t-test++, chi-square test*, and Fisher's exact test+.