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. 2012 Jun;22(6):1128–1138. doi: 10.1101/gr.133728.111

Figure 2.

Figure 2.

H3K27me3-enriched CpG island promoters are devoid of DNA methylation. (A,B) Examples of H3K27me3 ChIP-BS-seq data of HCT116 cells. H3K27me3 ChIP-BS-seq profiles are shown, as well as the derived DNA methylation data per covered CpG and per 200-bp window. Percentage methylation is color-coded as in Figure 1B. (C) Histograms showing the distribution of mean methylation in 300-bp windows throughout H3K27me3-enriched regions, as derived from H3K27me3 ChIP-BS-seq results. Windows were categorized according to functional genomic elements (intergenic, intron, exon, non-CpG island promoter, or CpG island promoter). (D) Average profiles of DNA methylation (blue), H3K27me3 (red), and CpG density (green) in regions flanking H3K27me3-enriched CpG islands, as determined from H3K27me3 ChIP-BS-seq data.