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. 2012 Jun 4;209(6):1105–1119. doi: 10.1084/jem.20112258

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© 2012 Franzke et al.

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Figure 7. — EGFR stimulation with TGF-α regulates terminal differentiation. (A) ECM-disrupted keratinocyte suspensions were incubated with and without 40 ng/ml TGF-α for 48 h, and total RNA was then analyzed by qPCR for keratin1, loricrin, and keratin14 (n = 3). (B) Suspension cultured keratinocytes analyzed for in vitro TGM activity (arrows). Bar, 20 µm. A17^ΔKC keratinocytes were cultured with 40 ng/ml TGF-α when indicated (n = 3 per group). (C) TGF-α ELISA in the supernatants of control and A17^ΔKC keratinocytes cultured for 24 h (n = 7). Results: mean ± SD. Student’s t test: *, P < 0.05; ***, P < 0.001.