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. 2012 Jun 4;209(6):1105–1119. doi: 10.1084/jem.20112258

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© 2012 Franzke et al.

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Figure 9. — Prolonged epidermal ADAM17 deficiency leads to chronic dermatitis. (A) Immunohistological staining of P60 epidermis with antibodies against the basal keratinocyte marker keratin14, hyperproliferation marker keratin 6, the early differentiation marker keratin1, and the terminal differentiation markers involucrin and loricrin. Arrows indicate staining localization. (B) Toluidine blue staining of back skin sections revealed a pronounced dermal accumulation of mast cells (arrows; n = 4). Bars: (A and B) 50 µm. (C) Concentrations of IgE and IgG1, measured by ELISA in serum of P60 animals (n ≥ 3). (D) Spleen weight in control, A17^ΔKC, and Egfr^ΔKC animals (n = 14). Bar, 1 cm. (E) Anti-B220 PE-stained B cell populations compared with controls in bone marrow flow cytometry (n ≥ 4). Data are mean ± SD. *, P < 0.05; **, P < 0.01; ***, P < 0.001.