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. 2012 Jun 4;209(6):1167–1181. doi: 10.1084/jem.20120340

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© 2012 Hoeffel et al.

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Figure 9. — Fetal liver monocytes contribute to epidermal LCs. Monocytes were purified from E13.5–E14.5 fetal liver of CD45.1⁺ mice and adoptively transferred in utero into unconditioned E13.5–E14.5 CD45.2⁺ congenic embryos. (A) Flow cytometry analysis of the progeny of adoptively transferred CD45.1⁺ monocytes in E19.5 epidermis 5 d after transfer. Control represents noninjected embryos (n = 9). (B) Percentage cells derived from donor monocytes for each injected embryos in the epidermis 5 d after injection. Bars show means of data from one representative experiment of three. (C) Expression of MHC-II on donor CD45.1⁺ monocyte-derived LC precursors at the indicated time points. Data are representative of 2 independent experiments (n = 2). (D) Percentage E18.5 donor (CD45.1⁺) LC precursors (CD11b⁺F480⁺CX3CR1/GFP^hi) derived from adoptively transferred Gr-1^hi or Gr-1^lo fetal liver monocytes (5 × 10⁵ per embryo). Error bars represent mean ± SEM of pooled data from 2 experiments (n = 2–5).