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. 2012 Jun 4;209(6):1057–1068. doi: 10.1084/jem.20120571

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© 2012 Andersson and Tracey

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 3. — Gateway reflex. Neural signals arising from soleus muscle contractions travel to the brain stem, and then descend into the sympathetic chain to the lumbar 5 level. This regulates the activity of adrenergic neurons that modulate the expression of CCL20 by endothelial cells, providing a crucial control mechanism that gates the entry of pathogenic T cells into the CNS.