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. Author manuscript; available in PMC: 2012 Jun 11.
Published in final edited form as: Surgery. 2009 Oct;146(4):714–722. doi: 10.1016/j.surg.2009.06.050

Fig 6.

Fig 6

Inhibition of γ-secretase by DAPT decreases cleaved Notch1 and downstream transcription factors and increases expression of the downstream Hath1 and CDX2. OE33 and OE19 were exposed to the γ-secretase inhibitor DAPT (20μM) for 24h. (A, B) RNA and (C) proteins were extracted and subjected to Real-Time PCR for the indicated mRNAs or to Western blot analysis for the proteins (A) OE33 (*P < .0001–P < .015), (B) OE19 (*P < .0001–P < .015), (C) OE19, (αP < 0.03; *P < .007, #P < .02). Controls were set to 1 and fold change is represented. n = 3–5.