Figure 1.

Inhibitory effect of AC on the proliferation of the HER-2/neu-overexpressing breast cancer cell lines MDA-MB-453 and BT-474. After incubation with different concentrations of AC (40–320 μg/mL) at 37°C for 24 h, the effect on (a) MDA-MB-231 and (b) BT-474 cell growth was examined by MTT assay. The number of viable cells after treatment is expressed as a percentage of the vehicle-only control, which was arbitrarily assigned 100%. The results are presented as the mean ± SD of three independent assays. *Significant difference in comparison to the control group (P < 0.05).