Figure 3.
Low pH accelerates recovery from FI. (A–C) The time course of recovery from FI at pH 7.4 (filled circles) and at pH 6.0 (open circles) for NaV1.2, NaV1.4, and NaV1.5, respectively. The averaged, normalized currents obtained during 0 mV test pulse, following an interpulse of increasing duration over a range of potentials (−130 to −80 mV, pulse protocol is shown at the bottom) are plotted vs. interpulse duration and fit with single exponential. Solid lines are single exponential fits to datapoints (Equation, Materials and Methods). Data for only −80 mV prepulse are shown. Data represent mean ± SEM (n = 10–12).