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. 2012 Jun 11;3:109. doi: 10.3389/fphar.2012.00109

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Copyright © 2012 Vilin, Peters and Ruben.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.

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Low pH alters kinetics of slow inactivation in Na_V1.2 and in Na_V1.5. (A) The time course of slow inactivation onset in Na_V1.2 at pH 7.4 (filled circles) and at pH 6.0 (open circles) is plotted vs. prepulse voltage as averaged and normalized currents, obtained with pulse protocol shown in (C) inset. (B) The time course of recovery from slow inactivation in Na_V1.2 at pH 7.4 (filled circles) and at pH 6.0 (open circles) is plotted vs. interpulse voltage as averaged and normalized currents, obtained with pulse protocol in (D) inset. (C) The time course of slow inactivation onset in Na_V1.5 at pH 7.4 (filled squares) and at pH 6.0 (open squares). (D) The time course of recovery from slow inactivation in Na_V1.5 at pH 7.4 (filled squares) and at pH 6.0 (open squares). Data represent mean ± SEM (n = 7–10). Asterisks denote statistical difference (p < 0.05).