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Parameters of steady-state fast inactivation in NaV1.2, NaV1.4, and NaV1.5 at pH 7.4 and 6.0.
| Channel | z (pH 7.4) | z (pH 6.0) | V1/2, mV (pH 7.4) | V1/2, mV (pH 6.0) |
|---|---|---|---|---|
| NaV1.2 | −4.6 ± 0.2 | −3.6 ± 0.1(1) | −50.1 ± 1.3 | −52.0 ± 1.6 |
| NaV1.4 | −3.5 ± 0.2 | −4.2 ± 0.3 | −67.5 ± 0.7 | −66.0 ± 0.4 |
| NaV1.5 | −4.4 ± 0.1 | −4.1 ± 0.1 | −80.6 ± 1.3 | −77.5 ± 1.4 |
(1)p < 0.05 vs. apparent valence; (z) at pH 7.4 in NaV1.2. n = 7–12.
