Table 2.
Comparison of results of AFB microscopy of first sputum specimens using direct smears, centrifuged smears, and SMFs for the diagnosis of pulmonary TB with Ogawa culture as the reference standard
| Methoda | % Sensitivity | % Specificity | % PPVb | % NPVc |
|---|---|---|---|---|
| Direct sputum smear microscopy | 56.1 (39.8, 71.5)d | 100.0 (97.6, 100) | 100 (85.2, 100) | 89.4 (83.7, 93.6) |
| Centrifuged sputum smear microscopy | 60.2 (48.9, 70.8) | 100.0 (98.4, 100) | 100 (92.9, 100) | 87.5 (82.9, 91.2) |
| SMF LM | 89.0 (80.2, 94.9) | 99.6 (97.6, 100) | 98.7 (92.7, 100) | 96.2 (93.0, 98.3) |
| SMF FM | 88.9 (80.0, 94.8) | 99.6 (97.6, 100) | 98.6 (92.6, 100) | 96.2 (93.0, 98.3) |
a
LM, LM using Kinyoun stain; FM, FM using auramine stain.
b
PPV, positive predictive value.
c
NPV, negative predictive value.
d
Values in parentheses are 95% CIs.