Table 2.
Comparisons of anti-HCV and HCV-Ag and a combination of anti-HCV plus HCV Ag tests to predict HCV viremia in a community screening (n = 405)a
| Test(s) | % Sen (95% CI) | % Spe (95% CI) | % Acc (95% CI) | PPV (95% CI) | NPV (95% CI) |
|---|---|---|---|---|---|
| Anti-HCV (S/CO = 40) | 98.9 (95.1 ∼ 99.9) | 98.1 (96.3 ∼ 99.2) | 98.3 (97.1 ∼ 99.5) | 93.9 (88.3 ∼ 98.7) | 99.7 (98.4 ∼ 100) |
| HCV Ag (3 fmol/liter) | 97.8 (93.4 ∼ 99.5) | 97.1 (95.3 ∼ 99.4) | 97.3 (95.3 ∼ 99.2) | 91.0 (84.5 ∼ 96.1) | 99.3 (98.5 ∼ 100) |
| HCV Ag (10 fmol/liter) | 94.6 (89.8 ∼ 98.3) | 98.7 (97.4 ∼ 99.6) | 97.8 (96.2 ∼ 99.1) | 95.7 (90.9 ∼ 99.3) | 98.4 (97.5 ∼ 99.4) |
| Anti-HCV (S/CO = 40) + HCVAg (3 fmol/liter) | 96.8 (92.5 ∼ 99.4) | 100 (99.3 ∼ 100) | 99.3 (98.5 ∼ 100) | 100 (97.7 ∼ 100) | 99.0 (98.4 ∼ 100) |
a
Abbreviations: Anti-HCV, anti-hepatitis C virus antibody; HCV Ag, hepatitis C virus core antigen; Sen, sensitivity; Spe, specificity; Acc, accuracy; PPV, positive predictive value; NPV, negative predictive value; CI, confidence interval.