Table 2.
WT MIC distributions of flucytosine for eight Candida species using CLSI BMD methods
Species | Incubation time (h) | No. of isolates tested | No. of isolates with MIC (μg/ml) of: |
||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
≤0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | ≥64 | |||
C. albicans | 24 | 8,007 | 3,295 | 2,496 | 1,218 | 530 | 246 | 93 | 31 | 22 | 18 | 10 | 48 |
48 | 7,241 | 409 | 3,147 | 1,633 | 721 | 708 | 297 | 154 | 37 | 30 | 15 | 90 | |
C. glabrata | 24 | 3,387 | 1,508 | 1,710 | 80 | 21 | 12 | 15 | 17 | 6 | 6 | 2 | 10 |
48 | 2,981 | 982 | 1,682 | 206 | 36 | 16 | 11 | 13 | 15 | 10 | 10 | ||
C. parapsilosis | 24 | 3,165 | 1,310 | 1,615 | 166 | 33 | 20 | 10 | 7 | 2 | 1 | 1 | |
48 | 2,274 | 315 | 1,160 | 615 | 133 | 32 | 6 | 5 | 4 | 4 | |||
C. tropicalis | 24 | 2,046 | 745 | 920 | 198 | 38 | 6 | 4 | 5 | 14 | 15 | 38 | 63 |
48 | 1,588 | 140 | 455 | 566 | 224 | 52 | 27 | 3 | 9 | 6 | 18 | 88 | |
C. krusei | 24 | 499 | 2 | 17 | 6 | 6 | 13 | 39 | 69 | 176 | 163 | 5 | 3 |
48 | 420 | 2 | 16 | 2 | 5 | 8 | 20 | 27 | 95 | 219 | 23 | 3 | |
C. lusitaniae | 24 | 85 | 10 | 66 | 1 | 4 | 1 | 1 | 2 | ||||
48 | 98 | 22 | 64 | 2 | 3 | 1 | 1 | 2 | 3 | ||||
C. dubliniensis | 24 | 84 | 61 | 9 | 13 | 1 | |||||||
48 | 44 | 39 | 2 | 2 | 1 | ||||||||
C. guilliermondii | 24 | 41 | 30 | 3 | 3 | 2 | 3 |