Table 3.
WT MIC distributions of itraconazole for eight Candida species using CLSI BMD methods
Species | Incubation Time (h) | No. of isolates tested | No. of isolates with MIC (μg/ml) of: |
||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
≤0.008 | 0.016 | 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | ≥8 | |||
C. albicans | 24 | 14,716 | 1,406 | 3,882 | 4,429 | 3,082 | 1,174 | 405 | 162 | 92 | 39 | 20 | 25 |
48 | 14,298 | 1,212 | 2,855 | 4,273 | 3,636 | 1,303 | 366 | 221 | 159 | 73 | 119 | 81 | |
C. glabrata | 24 | 5,769 | 17 | 77 | 203 | 330 | 463 | 1,162 | 1,932 | 973 | 362 | 128 | 122 |
48 | 5,846 | 5 | 16 | 32 | 73 | 196 | 593 | 1,726 | 1,871 | 618 | 335 | 381 | |
C. parapsilosis | 24 | 4,894 | 105 | 524 | 883 | 1,081 | 1,366 | 773 | 145 | 14 | 1 | 1 | 1 |
48 | 4,643 | 83 | 239 | 563 | 937 | 1,377 | 1,063 | 310 | 57 | 5 | 5 | 4 | |
C. tropicalis | 24 | 3,624 | 15 | 236 | 732 | 1,072 | 965 | 391 | 133 | 44 | 16 | 16 | 4 |
48 | 3,231 | 31 | 150 | 383 | 703 | 889 | 607 | 270 | 118 | 18 | 34 | 28 | |
C. krusei | 24 | 809 | 3 | 6 | 13 | 45 | 86 | 315 | 289 | 44 | 8 | ||
48 | 793 | 3 | 2 | 7 | 19 | 46 | 186 | 363 | 140 | 27 | |||
C. lusitaniae | 24 | 119 | 2 | 2 | 16 | 29 | 32 | 17 | 16 | 5 | |||
48 | 104 | 5 | 10 | 20 | 29 | 21 | 17 | 2 | |||||
C. dubliniensis | 24 | 85 | 1 | 3 | 37 | 21 | 14 | 7 | 2 | ||||
48 | 130 | 33 | 10 | 31 | 19 | 25 | 8 | 4 | |||||
C. guilliermondii | 24 | 61 | 1 | 4 | 8 | 2 | 17 | 24 | 5 | ||||
48 | 40 | 1 | 3 | 3 | 9 | 20 | 3 | 1 |