Table 4.

ECVs for amphotericin B, flucytosine, and itraconazole and eight Candida species

Species	Antifungal agent	Incubation time (h)	No. of isolates tested	MIC μg/ml		ECV (μg/ml) (%a)
				Range	Mode
C. albicans	Amphotericin B	24	9,252	≤0.03–4	0.5	2 (99.8)
		48	11,554	≤0.03–≥8	1	2 (99.2)
	Flucytosine	24	8,007	≤0.06–≥64	0.06	0.5 (94.2)
		48	7,241	≤0.06–≥64	0.12	1 (91.4)
	Itraconazole	24	14,716	≤0.008–≥8	0.03	0.12 (95.0)
		48	14,298	≤0.008–≥8	0.03	0.12 (92.9)
C. glabrata	Amphotericin B	24	3,117	≤0.03–4	1	2 (99.6)
		48	3,451	≤0.03–4	1	2 (98.7)
	Flucytosine	24	3,387	≤0.06–≥64	0.12	0.5 (98.0)
		48	2,981	≤0.06–≥64	0.12	0.5 (97.5)
	Itraconazole	24	5,796	≤0.008–≥8	0.5	2 (95.7)
		48	5,846	≤0.008–≥8	1	4 (97.9)
C. parapsilosis	Amphotericin B	24	3,107	≤0.03–4	1	2 (99.7)
		48	3,391	≤0.03–4	1	2 (97.3)
	Flucytosine	24	3,165	≤0.06–32	0.12	0.5 (98.7)
		48	2,274	≤0.06–≥64	0.12	0.5 (97.8)
	Itraconazole	24	4,894	≤0.008–≥8	0.12	0.5 (99.7)
		48	4,643	≤0.008–≥8	0.12	0.5 (98.5)
C. tropicalis	Amphotericin B	24	2,062	≤0.03–4	1	2 (99.8)
		48	2,373	≤0.03–≥8	1	2 (99.2)
	Flucytosine	24	2,046	≤0.06–≥64	0.12	0.5 (93.0)
		48	1,588	≤0.06–≥64	0.25	1 (90.5)
	Itraconazole	24	3,624	≤0.008–≥8	0.06	0.5 (97.8)
		48	3,231	≤0.008–≥8	0.12	0.5 (93.9)
C. krusei	Amphotericin B	24	577	≤0.03–4	1	2 (99.3)
		48	611	0.06–4	1	4 (100.0)
	Flucytosine	24	499	≤0.06–≥64	8	32 (99.4)
		48	419	≤0.06–≥64	16	32 (99.3)
	Itraconazole	24	809	≤0.008–2	0.25	1 (99.0)
		48	793	≤0.008–2	0.5	2 (100.0)
C. lusitaniae	Amphotericin B	24	71	0.06–2	1	2 (100.0)
		48	93	0.12–4	2	4 (100.0)
	Flucytosine	24	85	≤0.06–≥64	0.12	0.5 (95.3)
		48	98	≤0.06–≥64	0.12	1 (92.9)
	Itraconazole	24	119	≤0.008–1	0.12	0.5 (95.8)
		48	104	0.016–1	0.12	0.5 (98.1)
C. dubliniensis	Amphotericin B	48	75	≤0.03–2	0.5–1	2 (100.0)
	Flucytosine	24	84	0.12–1	0.12	0.5 (98.8)
		48	44	0.12–1	0.12	0.5 (97.7)
	Itraconazole	24	85	≤0.008–0.5	0.03	0.25 (97.6)
		48	130	≤0.008–0.5	NMb	0.25 (96.9)
C. guilliermondii	Amphotericin B	24	47	0.25–2	0.5	2 (100.0)
		48	83	0.06–2	0.5	2 (100.0)
	Flucytosine	24	41	0.12–8	0.12	1 (92.7)
	Itraconazole	24	61	0.016–1	0.5	1 (100.0)
		48	40	0.016–2	0.5	2 (100.0)

^aPercentage of isolates at less than or equal to the ECV (epidemiological cutoff value; μg/ml).

^bNM, no mode.