Table 7.
Viremia in 5- to 8-week-old A129 mice after ID infection with WT or mutant CHIKV strain AF15561 or vaccine strain 181/25
| Virus straina | Day 1 postinfection |
Day 3 postinfection |
||
|---|---|---|---|---|
| No. of animals positive/total no. inoculated | Mean titerb of positive animals ± SD | No. of animals positive | Mean titerb of positive animals ± SD | |
| 15561 | 8/9 | 5.0 ± 0.8 | 9/9 | 8.2 ± 1.0 |
| 15561/3x | 7/9 | 4.6 ± 2.2 | 9/9 | 7.7 ± 0.9 |
| 15561/E2-82 | 8/9 | 3.3 ± 1.1 | 9/9 | 7.0 ± 0.8 |
| 15561/E2-12 | 8/9 | 2.9 ± 0.9 | 9/9 | 6.5 ± 1.3 |
| 15561/2xE2 | 7/9 | 2.8 ± 1.2 | 8/9 | 4.9 ± 1.5 |
| 181/25 | 7/9 | 2.5 ± 1.0 | 9/9 | 5.0 ± 0.5 |
a
See Fig. 5 for strain designations.
b
Titers are in log10 PFU/ml of serum, and the limit of detection of the assay was 0.9 log10 PFU/ml of serum.